Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Purine nucleotides are critically important for the normal functioning of cells due to their
myriad of activities. It is important for cells to maintain a balance in the pool sizes of the …

Cells use strategic metabolites to sense the metabolome and accordingly modulate gene
expression. Here, we show that the purine and phosphate pathways are positively regulated …

Which transcription factors control the distribution of metabolic fluxes under a given
condition? We address this question by systematically quantifying metabolic fluxes in 119 …

Ashbya gossypii is a natural riboflavin overproducer used in the industrial production of the
vitamin. We have isolated an insertional mutant exhibiting higher levels of riboflavin …

The pathogenic yeast, Candida albicans, and other microbes must be able to handle drastic
changes in nutrient availability within the human host. Copper, iron, and phosphate are …

The organization of chromatin domains in the nucleus is an important factor in gene
regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear …

Background Two reference strains have been sequenced from the mushroom Coprinopsis
cinerea, monokaryon Okayama 7/# 130 (OK130) and the self-compatible homokaryon …

Candida albicans is an opportunistic human fungal pathogen that causes superficial fungal
infections and lethal systemic infections. To colonize and establish infections, C. albicans …

Proper modulation of promoter chromatin architecture is crucial for gene regulation in order
to precisely and efficiently orchestrate various cellular activities. Previous studies have …