FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

Heparin is a major anticoagulant with activity mediated primarily through its interaction with
antithrombin (AT). Heparan sulfate (HS), structurally related to heparin, binds a wide range …

Polyanions are important sensing targets because of their wide variety of biological
activities. We report a novel polyanion-selective fluorescence sensing system composed of …

Adeno-associated virus serotype 2 (AAV-2) is a leading candidate vector for gene therapy.
Cell entry starts with attachment to a primary receptor, Heparan Sulfate Proteoglycan …

U'S'PATENT DOCUMENTS taining substituted ammonium and/or polyanion, and option jié 2
gicoiau et 3% ally With a desired therapeutic or imaging entity. The present 5'0 13'5 56 A …

The 22 members of the fibroblast growth factor (FGF) family have been implicated in cell
proliferation, differentiation, survival, and migration. They are required for both development …

Sucralfate is a basic aluminium salt of sucrose octasulphate which was orally employed for
prevention and treatment of several gastrointestinal diseases including gastroesophageal …

The behavior of the proteome reflects spatial and temporal organization both within and
without cells. We propose that various macromolecular entities possessing polyanionic …

Heparin is a highly sulfated polysaccharide that regulates a variety of cellular processes by
interaction with a host of proteins. We report the preparation of synthetic heparin …

The polyanionic nature and the ability to interact with proteins with different affinities are
properties of sulfated glycosaminoglycans (GAGs) that determine their biological function. In …