Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

A large body of preclinical and clinical data shows that the central melanocortin system is a
promising therapeutic target for treating various metabolic disorders such as obesity and …

We present a systematic assessment of polygenic risk score (PRS) prediction across more
than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse …

Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

Obesity contributes substantially to the global burden of disease and has a significant
heritable component. Recent large-scale exome sequencing studies identified several …

Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain.
Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

Linear growth is a complex process and is considered one of the best indicators of children's
well-being and health. Genetics, epigenetics and environment (mainly stress and availability …

Summary Type 2 diabetes (T2D) is a heritable metabolic disorder. While population studies
have identified hundreds of common genetic variants associated with T2D, the role of rare …

The hypothalamic melanocortin system is critically involved in sensing stored energy and
communicating this information throughout the brain, including to brain regions controlling …