HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Serotonergic hallucinogens produce profound changes in perception, mood, and cognition.
These drugs include phenylalkylamines such as mescaline and 2, 5-dimethoxy-4 …

Purpose.: It has been shown that sunlight or bright indoor light can inhibit the development
of deprivation myopia in chicks. It remains unclear whether light merely acts on deprivation …

Blockade of the serotonin 5-HT 2A G protein-coupled receptor (5-HT 2A R) is a fundamental
pharmacological characteristic of numerous antipsychotic medications, which are FDA …

A large series of β-carbolines was examined for their ability to bind at [3H] agonist-labeled 5-
HT2A serotonin receptors. Selected β-carbolines were also examined at 5-HT2C serotonin …

An efficient and stereoselective reaction between 3-isothiocyanato oxindoles and
isatins/isatinimines has been developed to afford structurally diverse dispiro [oxazolidine-2 …

Imidazolones represent an important class of heterocycles present in a wide range of
pharmaceuticals, metabolites, and bioactive natural products and serve as the active …

Despite the appreciation for electro-organic synthesis, postmulticomponent reaction
transformation chemistry rarely exploits this powerful technology. Herein, we explore post …

Dimethyl acetylenedicarboxylate (DMAD) is an electron-deficient acetylenic compound
having two reactive ester groups. It is a privileged and advantaged molecule, which …

Glial activation and neuroinflammatory processes play an important role in the pathogenesis
of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and HIV …