Targeting ROCK/LIMK/cofilin signaling pathway in cancer

MH Lee, JK Kundu, JI Chae, JH Shim - Archives of pharmacal research, 2019 - Springer
Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase
(LIMK)/cofilin-signaling cascades are stimulated by receptor tyrosine kinases, G protein …

The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer

PP Gao, XW Qi, N Sun, YY Sun, Y Zhang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Reversible phosphorylation of proteins, controlled by kinases and phosphatases, is involved
in various cellular processes. Dual-specificity phosphatases (DUSPs) can dephosphorylate …

[HTML][HTML] Cofilin-1 signaling mediates epithelial-mesenchymal transition by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation in colorectal …

ACM Sousa-Squiavinato, MR Rocha… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Colorectal cancer (CRC) is frequently a lethal disease because of metastasis. Actin
cytoskeletal rearrangement is an essential step in cell migration during activation of the …

DANCR promotes HCC progression and regulates EMT by sponging miR‐27a‐3p via ROCK1/LIMK1/COFILIN1 pathway

D Guo, Y Li, Y Chen, D Zhang, X Wang, G Lu… - Cell …, 2019 - Wiley Online Library
Objectives This research aims to verify that the long non‐coding RNA differentiation
antagonizing nonprotein coding RNA (LncRNA DANCR) could modulate the proliferation …

[HTML][HTML] MiR-128-3p suppresses breast cancer cellular progression via targeting LIMK1

J Zhao, D Li, L Fang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Breast cancer is the most common malignancy in women all over the world. MiRNAs are a
type of small noncoding RNA that can regulate various cellular processes via binding …

lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging

Y Zhang, X Liu, Q Li, Y Zhang - Cancer management and research, 2019 - Taylor & Francis
Background lncRNAs are widely involved in multiple malignancies including colorectal
cancer (CRC). The expression and function of long intergenic non-protein coding RNA 460 …

Deciphering the methylation landscape in breast cancer: diagnostic and prognostic biosignatures through automated machine learning

M Panagopoulou, M Karaglani, VG Manolopoulos… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BrCa) is characterized by aberrant DNA methylation. We
leveraged high-throughput methylation data from BrCa and normal breast tissues and …

Dasatinib inhibits lung cancer cell growth and patient derived tumor growth in mice by targeting LIMK1

M Zhang, J Tian, R Wang, M Song, R Zhao… - Frontiers in Cell and …, 2020 - frontiersin.org
Lung cancer is a leading cause cancer-related death with diversity. A promising approach to
meet the need for improved cancer treatment is drug repurposing. Dasatinib, a second …

HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer

KJ Cheng, MA Alshawsh, EH Mejia Mohamed… - Cellular Oncology, 2020 - Springer
Background In recent years, the high mobility group box-1 (HMGB1) protein, a damage-
associated molecular pattern (DAMP) molecule, has been found to play multifunctional roles …

PDZ and LIM domain-encoding genes: their role in cancer development

X Jiang, Z Xu, S Jiang, H Wang, M Xiao, Y Shi, K Wang - Cancers, 2023 - mdpi.com
Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …