Clostridium difficile infection

WK Smits, D Lyras, DB Lacy, MH Wilcox… - Nature reviews Disease …, 2016 - nature.com
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

Pathogenicity and virulence of Clostridioides difficile

JE Buddle, RP Fagan - Virulence, 2023 - Taylor & Francis
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Update on antimicrobial resistance in Clostridium difficile: resistance mechanisms and antimicrobial susceptibility testing

Z Peng, D Jin, HB Kim, CW Stratton, B Wu… - Journal of clinical …, 2017 - Am Soc Microbiol
Oral antibiotics such as metronidazole, vancomycin and fidaxomicin are therapies of choice
for Clostridium difficile infection. Several important mechanisms for C. difficile antibiotic …

Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection

P Spigaglia - Therapeutic advances in infectious disease, 2016 - journals.sagepub.com
Clostridium difficile epidemiology has changed in recent years, with the emergence of highly
virulent types associated with severe infections, high rates of recurrences and mortality …

[HTML][HTML] The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee

MJ Ellington, O Ekelund, FM Aarestrup… - Clinical microbiology …, 2017 - Elsevier
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility
from a single assay. The European Committee on Antimicrobial Susceptibility Testing …

Renaissance of vancomycin: Approaches for breaking antibiotic resistance in multidrug-resistant bacteria

E Mühlberg, F Umstätter, C Kleist… - Canadian journal of …, 2020 - cdnsciencepub.com
The emergence of multidrug-resistant bacteria demands innovations in the development of
new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

Antimicrobial resistance and susceptibility testing of anaerobic bacteria

AN Schuetz - Clinical infectious diseases, 2014 - academic.oup.com
Antimicrobial Resistance and Susceptibility Testing of Anaerobic Bacteria | Clinical Infectious
Diseases | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

Two codependent routes lead to high-level MRSA

AF Adedeji-Olulana, K Wacnik, L Lafage… - Science, 2024 - science.org
Methicillin-resistant Staphylococcus aureus (MRSA), in which acquisition of mecA [which
encodes the cell wall peptidoglycan biosynthesis component penicillin-binding protein 2a …

Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms

SS Banawas - BioMed research international, 2018 - Wiley Online Library
Clostridium difficile (C. difficile) is the most prevalent causative pathogen of healthcare‐
associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile …