CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Astrocytes regulate central nervous system development, maintain its homeostasis and
orchestrate repair upon injury. Emerging evidence support functional specialization of …

Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic
development and function. This process is regulated by transcellular interactions between …

The glymphatic system is a recently defined brain‐wide network of perivascular spaces
along which cerebrospinal fluid (CSF) and interstitial solutes exchange. Astrocyte endfeet …

Defects in the astrocytic membrane protein MLC1, the adhesion molecule GlialCAM or the
chloride channel ClC-2 underlie human leukoencephalopathies. Whereas GlialCAM binds …

Defective astrocyte function due to a genetic mutation can have major consequences for
microglia and oligodendrocyte physiology, which in turn affects the white matter integrity of …

Objective To provide an overview of clinical and MRI characteristics of the different variants
of the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts (MLC) …

Astrocytes are the most abundant cell type in the CNS (central nervous system). They exert
multiple functions during development and in the adult CNS that are essential for brain …

Objective Megalencephalic leukoencephalopathy with cysts (MLC) is a genetic infantile‐
onset disease characterized by macrocephaly and white matter edema due to loss of MLC 1 …

Absence of the astrocyte-specific membrane protein MLC1 is responsible for
megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare type of …