Intercellular mitochondrial transfer as a means of tissue revitalization

D Liu, Y Gao, J Liu, Y Huang, J Yin, Y Feng… - Signal transduction and …, 2021 - nature.com
As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion
frequently undergoes morphological or positional changes when responding to various …

Mechanisms of mesenchymal stem/stromal cell function

JL Spees, RH Lee, CA Gregory - Stem cell research & therapy, 2016 - Springer
The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

T Saha, C Dash, R Jayabalan, S Khiste… - Nature …, 2022 - nature.com
Cancer progresses by evading the immune system. Elucidating diverse immune evasion
strategies is a critical step in the search for next-generation immunotherapies for cancer …

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes

H Scheiblich, F Eikens, L Wischhof, S Opitz, K Jüngling… - Neuron, 2024 - cell.com
Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …

[HTML][HTML] Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts

ÂC Crespo, S Mulik, F Dotiwala, JA Ansara, SS Santara… - Cell, 2020 - cell.com
Maternal decidual NK (dNK) cells promote placentation, but how they protect against
placental infection while maintaining fetal tolerance is unclear. Here we show that human …

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

T Baumann, A Dunkel, C Schmid, S Schmitt… - Nature …, 2020 - nature.com
Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs),
populate inflamed or cancerous tissue and block immune cell effector functions. The lack of …

Regenerative abilities of mesenchymal stem cells through mitochondrial transfer

S Paliwal, R Chaudhuri, A Agrawal… - Journal of biomedical …, 2018 - Springer
The past decade has witnessed an upsurge in studies demonstrating mitochondrial transfer
as one of the emerging mechanisms through which mesenchymal stem cells (MSCs) can …

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

X Wang, HH Gerdes - Cell Death & Differentiation, 2015 - nature.com
Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in
culture and in tissues. They mediate intercellular communication ranging from electrical …

Antigen presentation by extracellular vesicles from professional antigen-presenting cells

MFS Lindenbergh, W Stoorvogel - Annual review of …, 2018 - annualreviews.org
The initiation and maintenance of adaptive immunity require multifaceted modes of
communication between different types of immune cells, including direct intercellular …

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

M Tardivel, S Bégard, L Bousset, S Dujardin… - Acta neuropathologica …, 2016 - Springer
A given cell makes exchanges with its neighbors through a variety of means ranging from
diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin …