Glycogen is a branched polymer of glucose that acts as a store of energy in times of
nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of …

Alzheimer's disease (AD) is the most common form of dementia present in older adults; its
etiology involves genetic and environmental factors. In recent years, epidemiological studies …

Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy. The
disease usually manifests in previously healthy adolescents, and death commonly occurs …

Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins,
lipids and damaged organelles to the lysosomes for degradation and elimination. The …

Starch is globally important as a source of food and, in addition, has a wide range of
industrial applications. Much of this agriculturally produced starch is synthesized in …

Starch‐active enzymes often possess starch‐binding domains (SBDs) mediating attachment
to starch granules and other high molecular weight substrates. SBDs are divided into nine …

Lafora disease is a progressive myoclonus epilepsy with onset typically in the second
decade of life and death within 10 years. Lafora bodies, deposits of abnormally branched …

Laforin is the only phosphatase in the animal kingdom that contains a carbohydrate-binding
module. Mutations in the gene encoding laforin result in Lafora disease, a fatal autosomal …

Lafora disease (LD), a fatal neurodegenerative disorder characterized by the presence of
intracellular inclusions called Lafora bodies (LBs), is caused by loss-of-function mutations in …

Obesity and age are important risk factors for cardiovascular disease. However, the
signaling mechanism linking obesity with age-related vascular senescence is unknown …