Robust nucleus/cell detection and segmentation in digital pathology and microscopy images: a comprehensive review

F Xing, L Yang - IEEE reviews in biomedical engineering, 2016 - ieeexplore.ieee.org
Digital pathology and microscopy image analysis is widely used for comprehensive studies
of cell morphology or tissue structure. Manual assessment is labor intensive and prone to …

Accurate cervical cell segmentation from overlapping clumps in pap smear images

Y Song, EL Tan, X Jiang, JZ Cheng, D Ni… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Accurate segmentation of cervical cells in Pap smear images is an important step in
automatic pre-cancer identification in the uterine cervix. One of the major segmentation …

Deep learning for fast spatially varying deconvolution

K Yanny, K Monakhova, RW Shuai, L Waller - Optica, 2022 - opg.optica.org
Deconvolution can be used to obtain sharp images or volumes from blurry or encoded
measurements in imaging systems. Given knowledge of the system's point spread function …

Evaluation of deep learning architectures for complex immunofluorescence nuclear image segmentation

F Kromp, L Fischer, E Bozsaky… - … on Medical Imaging, 2021 - ieeexplore.ieee.org
Separating and labeling each nuclear instance (instance-aware segmentation) is the key
challenge in nuclear image segmentation. Deep Convolutional Neural Networks have been …

Unsupervised learning for cell-level visual representation in histopathology images with generative adversarial networks

B Hu, Y Tang, I Eric, C Chang, Y Fan… - IEEE journal of …, 2018 - ieeexplore.ieee.org
The visual attributes of cells, such as the nuclear morphology and chromatin openness, are
critical for histopathology image analysis. By learning cell-level visual representation, we …

Multi-pass fast watershed for accurate segmentation of overlapping cervical cells

A Tareef, Y Song, H Huang, D Feng… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
The task of segmenting cell nuclei and cytoplasm in pap smear images is one of the most
challenging tasks in automated cervix cytological analysis due to specifically the presence of …

Discrimination of cell cycle phases in PCNA-immunolabeled cells

F Schönenberger, A Deutzmann, E Ferrando-May… - BMC …, 2015 - Springer
Background Protein function in eukaryotic cells is often controlled in a cell cycle-dependent
manner. Therefore, the correct assignment of cellular phenotypes to cell cycle phases is a …

Automated blob detection using iterative Laplacian of Gaussian filtering and unilateral second-order Gaussian kernels

G Wang, C Lopez-Molina, B De Baets - Digital Signal Processing, 2020 - Elsevier
Detecting overlapping blob objects is a classical, yet challenging problem in the image
processing field. In this paper, we propose an automated blob detection method that is able …

An end-to-end deep learning histochemical scoring system for breast cancer TMA

J Liu, B Xu, C Zheng, Y Gong… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
One of the methods for stratifying different molecular classes of breast cancer is the
Nottingham prognostic index plus, which uses breast cancer relevant biomarkers to stain …

Real-time, deep-learning aided lensless microscope

J Wu, V Boominathan, A Veeraraghavan… - Biomedical Optics …, 2023 - opg.optica.org
Traditional miniaturized fluorescence microscopes are critical tools for modern biology.
Invariably, they struggle to simultaneously image with a high spatial resolution and a large …