HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be
extinguished, extinction memories are fragile. The resilience of fear memories to extinction …

Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making.
Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …

Nucleus accumbens neurons serve to integrate information from cortical and limbic regions
to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

Extinction is a form of inhibitory learning that suppresses a previously conditioned response.
Both fear and drug seeking are conditioned responses that can lead to maladaptive …