Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Nature encodes the information required for life in two fundamental biopolymers: nucleic
acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of …

The small molecule epiberberine (EPI) is a natural alkaloid with versatile bioactivities
against several diseases including cancer and bacterial infection. EPI can induce the …

Four probe chemistries are characterized and compared with respect to thermal
denaturation temperatures (Tms), thermodynamic parameters associated with duplex …

Gamma peptide nucleic acids (γPNAs), ie, single-stranded PNA strands that are modified at
the γ-position with (R)-diethylene glycol, and Invader probes, ie, DNA duplexes with+ 1 …

Three probe chemistries are evaluated with respect to thermal denaturation temperatures,
UV-Vis and fluorescence characteristics, recognition of complementary and mismatched …

High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading
stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off …

The level of pyrophosphatase (PPase) expression has been suggested as a potential
biomarker of various cancers, and its prognostic value has been evaluated in patients …

Human telomere DNA plays a vital role in genome integrity control and carcinogenesis as
an indication for extensive cell proliferation. Herein, silver nanoclusters (Ag NCs) templated …

Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a
group of chemists and biochemists in a memorable Science paper [1]. At that time, it was …