Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Activation of naive T cells by antigen-presenting cells (APCs) is an essential step in
mounting an adaptive immune response. It is known that antigen recognition and T cell …

Despite the vital role of mechanical forces in biology, it still remains a challenge to image
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …

Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …

Modern machines, which are composed of force-generating motors, force sensors, and load-
bearing structures, enabled the industrial revolution and are foundational to human …

Cells are known to exert forces to sense their physical surroundings for guidance of motion
and fate decisions. Here, we propose that cells might do mechanical work to drive their own …

Actomyosin networks provide the major contractile machinery for regulating cell and tissue
morphogenesis during development. These networks undergo dynamic rearrangements …

Advances in academic and clinical studies during the last several years have resulted in
practical outcomes in adoptive immune therapy of cancer. Immune cells can be programmed …

The proteins involved in cells' mechanobiological processes have evolved specialized and
surprising responses to applied forces. Biochemical transformations that show catch-to-slip …

Chimeric antigen receptor (CAR) T-cell therapies exploit facile antibody-mediated targeting
to elicit useful immune responses in patients. This work directly compares binding profiles of …