Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …

Mobility is an intrinsic feature of the animal kingdom that stimulates evolutionary processes
and determines the biological success of animals. Skeletal muscle is the primary driver of …

Background Obese and lean pig breeds show obvious differences in muscle growth;
however, the molecular mechanism underlying phenotype variation remains unknown …

Congenital heart defects (CHDs) are the most common of all birth defects, yet molecular
mechanism (s) underlying highly prevalent atrial septal defects (ASDs) and ventricular …

Genetic information encoded in chromosomal DNA is challenged by intrinsic and
exogenous sources of DNA damage. DNA double-strand breaks (DSBs) are extremely …

Myocardin, a serum response factor (SRF)-dependent cofactor, is a potent activator of
smooth muscle gene activity but a poor activator of cardiogenic genes in pluripotent 10T1/2 …

SUMO modification regulates the activity of numerous transcription factors that have a direct
role in cell-cycle progression, apoptosis, cellular proliferation, and development, but its role …

Proliferation and fusion of myoblasts are needed for the generation and repair of
multinucleated skeletal muscle fibers in vivo. Studies of myocyte differentiation, cell fusion …

TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by
ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes to substrate …

Sortilin has been implicated in the formation of insulin-responsive GLUT4 storage vesicles in
adipocytes by regulating sorting events between the trans-Golgi-network and endosomes …