Genistein: A promising modulator of apoptosis and survival signaling in cancer
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-
expanding spectrum of pharmacological benefits. In addition to health benefits such as …
expanding spectrum of pharmacological benefits. In addition to health benefits such as …
Development of radiation countermeasure agents for acute radiation syndromes
B Guan, D Li, A Meng - Animal Models and Experimental …, 2023 - Wiley Online Library
The risk of internal and external exposure to ionizing radiation (IR) has increased alongside
the development and implementation of nuclear technology. Therefore, serious security …
the development and implementation of nuclear technology. Therefore, serious security …
Radiation-induced multi-organ injury
O Molinar-Inglis, AL DiCarlo, PJ Lapinskas, CI Rios… - 2024 - Taylor & Francis
Purpose Natural history studies have been informative in dissecting radiation injury,
isolating its effects, and compartmentalizing injury based on the extent of exposure and the …
isolating its effects, and compartmentalizing injury based on the extent of exposure and the …
Pharmacokinetic and metabolomic studies with a BIO 300 oral powder formulation in nonhuman primates
Y Li, M Girgis, M Jayatilake, AA Serebrenik… - Scientific reports, 2022 - nature.com
BIO 300, a pharmaceutical formulation of genistein, is being developed as a radiation
countermeasure to treat hematopoietic acute radiation syndrome (H-ARS) and the delayed …
countermeasure to treat hematopoietic acute radiation syndrome (H-ARS) and the delayed …
An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024
JG Kiang, G Cannon, VK Singh - Radiation research, 2024 - meridian.allenpress.com
Preparation for medical responses to major radiation accidents, further driven by increases
in the threat of nuclear warfare, has led to a pressing need to understand the underlying …
in the threat of nuclear warfare, has led to a pressing need to understand the underlying …
Space exploration as a catalyst for medical innovations
J Scarpa, S Parazynski, G Strangman - Frontiers in Medicine, 2023 - frontiersin.org
Aerospace research has a long history of developing technologies with industry-changing
applications and recent history is no exception. The expansion of commercial spaceflight …
applications and recent history is no exception. The expansion of commercial spaceflight …
[HTML][HTML] The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice
MD Kaytor, AA Serebrenik, K Lapanowski… - Translational Lung …, 2023 - ncbi.nlm.nih.gov
Background Radiotherapy for non-small cell lung cancer (NSCLC) can be dose-limiting due
to treatment-related toxicities. Genistein has been shown to be a robust radioprotective …
to treatment-related toxicities. Genistein has been shown to be a robust radioprotective …
Safety, pharmacokinetics, and biomarkers of an amorphous solid dispersion of genistein, a radioprotectant, in healthy volunteers
AA Serebrenik, CW Verduyn… - Clinical Pharmacology in …, 2023 - Wiley Online Library
A pharmaceutical formulation of genistein, produced as an amorphous solid dispersion by
hot melt extrusion (genistein HME), has been developed that can be administered …
hot melt extrusion (genistein HME), has been developed that can be administered …
Biomarkers to Predict Lethal Radiation Injury to the Rat Lung
M Medhora, F Gao, T Gasperetti, J Narayanan… - International Journal of …, 2023 - mdpi.com
Currently, there are no biomarkers to predict lethal lung injury by radiation. Since it is not
ethical to irradiate humans, animal models must be used to identify biomarkers. Injury to the …
ethical to irradiate humans, animal models must be used to identify biomarkers. Injury to the …