Abstract Zinc α2-glycoprotein (ZAG) is a protein of interest because of its ability to play many
important functions in the human body, including fertilization and lipid mobilization. After the …

Sperm are attracted by chemical factors that are released by the egg—a process called
chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine …

Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second
messenger cyclic adenosine 3′, 5′ monophosphate (cAMP). sAC is distinct from the more …

The sperm‐specific CatSper channel controls the intracellular Ca2+ concentration ([Ca2+] i)
and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by …

We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC)
are sterile and produce spermatozoa with deficits in progressive motility and are unable to …

In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The
individual components of this equilibrium (ie, CO 2, HCO 3−, and H+), which must be sensed …

The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility
and male fertility, and for Ca2+ entry evoked by alkaline depolarization. In the absence of …

The source and composition of seminal plasma has previously been shown to alter the
ability of spermatozoa to survive cryopreservation. In the present study, the ionic and …

The HCO3− anion activates sperm motility, an important early step in capacitation, by
increasing flagellar beat frequency through a pathway that requires the atypical adenylyl …

The sperm-specific Ca 2+ channel CatSper (cation channel of sperm) controls the influx of
Ca 2+ into the flagellum and, thereby, the swimming behavior of sperm. A hallmark of human …