Emerging prospects of mRNA cancer vaccines: mechanisms, formulations, and challenges in cancer immunotherapy

UE Laila, W An, ZX Xu - Frontiers in Immunology, 2024 - frontiersin.org
Cancer continues to pose an alarming threat to global health, necessitating the need for the
development of efficient therapeutic solutions despite massive advances in the treatment …

[HTML][HTML] Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs

S Deng, H Shao, H Shang, L Pang, X Chen, J Cao… - Vaccines, 2024 - mdpi.com
Background/Objectives: The endosomal escape of lipid nanoparticles (LNPs) is crucial for
efficient mRNA-based therapeutics. Here, we present a cationic polymeric micelle (cPM) as …