The genetic basis is now known for several disorders of neuronal migration in the
developing cerebral cortex. Identification of the cellular processes mediated by the …

Neurons are one of the highly polarized cells in the body. One of the fundamental issues in
neuroscience is how neurons establish their polarity; therefore, this issue fascinates many …

ATM kinase plays a central role in signaling DNA double‐strand breaks to cell cycle
checkpoints and to the DNA repair machinery. Although the exact mechanism of ATM …

Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based
molecular motor dynein result in lissencephaly. However, a functional link between DCX …

Here we studied doublecortin (DCX) in cultured hippocampal and sympathetic neurons
during axonal development. In both types of neurons, DCX is abundant in the growth cone …

Classical lissencephaly is a human developmental brain disorder characterized by a paucity
of cortical gyration and thickening of the cortical gray matter, leading to severe epilepsy and …

We investigated the postnatal effects of embryonic knockdown and overexpression of the
candidate dyslexia gene homolog Kiaa0319. We used in utero electroporation to transfect …

Subcortical band heterotopia (SBH) or double cortex is associated with significant
impairments in neocortical function including mental retardation and epilepsy. Mutant alleles …

Embryonic knockdown of candidate dyslexia susceptibility gene (CDSG) homologs in
cerebral cortical progenitor cells in the rat results in acute disturbances of neocortical …

Neuritogenesis is crucial for establishing proper neuronal connections during brain
development; its failure causes neurodevelopmental defects. Cullin-RING E3 ubiquitin …