Atorvastatin post-conditioning attenuates myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress–related apoptosis

J Xia, F Xu, Y Qu, D Song, H Shen, X Liu - Shock, 2014 - journals.lww.com
The present study examined whether atorvastatin, when used for pharmacological
postconditioning, attenuated myocardial ischemia-reperfusion (I/R) injury in a manner …

A low‐dose combination of fluvastatin and valsartan: a new “drug” and a new approach for decreasing the arterial age

M Janić, M Lunder, M Šabovič - BioMed Research International, 2015 - Wiley Online Library
We have developed a new “drug” and approach that appear to be effective in reducing
arterial age. This “drug” represents a low, subtherapeutic dose of statin and sartan and …

Differential effects of Losartan and Atorvastatin in partial and full thickness burn wounds

JJ Akershoek, KM Brouwer, M Vlig, BKHL Boekema… - PloS one, 2017 - journals.plos.org
Healing of burn wounds is often associated with scar formation due to excessive
inflammation and delayed wound closure. To date, no effective treatment is available to …

LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats

Q Zhao, X Hu, L Shao, G Wu, J Du, J Xia - Heart and vessels, 2014 - Springer
This study aims to determine the effect of Lipoxin (LX) A 4 on myocardial ischemia
reperfusion injury (MIRI) in rats and the related molecular mechanisms. Male SD rats were …

Design of fixed dose combination and physicochemical characterization of enteric-coated bilayer tablet with circadian rhythmic variations containing telmisartan and …

D Luo, JH Kim, C Park, E Oh, JB Park, JH Cui… - International Journal of …, 2017 - Elsevier
The aim of this study was to investigate a fixed dose combination (FDC) of telmisartan (TEL)
and pravastatin sodium (PRA) in enteric-coated bilayer tablets, which was designed for once …

Influence of dual antiplatelet therapy on mean platelet volume in patients with coronary artery disease undergoing percutaneous coronary intervention

T Higaki, S Kurisu, N Watanabe, H Ikenaga… - Heart and vessels, 2016 - Springer
Mean platelet volume (MPV) is a well-established marker of platelet activation, and recent
studies have shown that platelet activation is central to the processes in the pathophysiology …

Cardioprotective effect of atorvastatin alone or in combination with remote ischemic preconditioning on the biochemical changes induced by ischemic/reperfusion …

ESEL Desoky, AKM Hassan, SY Salem, SA Fadil… - International Journal of …, 2016 - Elsevier
Background Atorvastatin and remote ischemic preconditioning (RIPC) have beneficial
cardiovascular protective effects. The aim of the study was to investigate possible effect of …

Inhibition of Rho-kinase is involved in the therapeutic effects of atorvastatin in heart ischemia/reperfusion

C Cheng, XB Liu, SJ Bi, QH Lu… - Experimental and …, 2020 - spandidos-publications.com
The aim of the present study was to investigate the effects of atorvastatin against heart
ischemia/reperfusion (I/R) injury and its potential underlying mechanism. Rats were …

Low-dose fluvastatin and valsartan rejuvenate the arterial wall through telomerase activity increase in middle-aged men

M Janić, M Lunder, P Cerkovnik… - Rejuvenation …, 2016 - liebertpub.com
Abstract Background and Aim: Previously, we have shown that slightly to moderately aged
arteries in middle-aged males can be rejuvenated functionally by sub-therapeutic, low-dose …

Safety profile of atorvastatin in the role of burn wound injury conversion

T Boyko, C Marin, G Furnari, W Flynn… - The American Journal of …, 2020 - Elsevier
Background Atorvastatin could be beneficial in the treatment of burn patients to prevent burn
wound progression from partial to full thickness. Our primary aim is to evaluate the safety of …