Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic
microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic …

Oxidative stress has been linked to the pathogenesis of the major complications of diabetes
in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a …

Chronic inflammation and persistent oxidative stress contribute to the development and
progression of vascular proliferative diseases. We hypothesized that the proinflammatory …

Proximal tubular epithelial cells (PTEC) in the S1 segment of the kidney abundantly express
sodium-glucose co-transporters (SGLT) that play a critical role in whole body glucose …

Oxidized low-density lipoprotein (oxLDL) induces endothelial cell death through the
activation of NF-κB and AP-1 pathways. TRAF3IP2 is a redox-sensitive cytoplasmic adapter …

Endothelial dysfunction is a key event in the progression of atherosclerosis with diabetes.
Increasing cell apoptosis may lead to endothelial dysfunction. Apigenin and naringenin are …

Sustained induction and activation of matrixins (matrix metalloproteinases or MMPs), and
the destruction and deposition of extracellular matrix (ECM), are the hallmarks of cardiac …

Chronic low-grade inflammation has been identified as a major contributor in the
development of atherosclerosis. Nuclear Factor-κappa B (NF-κB) is a critical transcription …

Both oxidative stress and inflammation contribute to chronic hypertension‐induced
myocardial fibrosis and adverse cardiac remodeling. Here we investigated whether …

Type 2 diabetes mellitus (T2DM) is a multifactorial and multigenetic disease, and its
pathogenesis is complex and largely unknown. In the present study, microarray data …