Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

GJ Kelloff, JM Hoffman, B Johnson, HI Scher… - Clinical Cancer …, 2005 - AACR
[18F] Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) assesses a
fundamental property of neoplasia, the Warburg effect. This molecular imaging technique …

Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer

BDP O'Neill, G Brown, RJ Heald, D Cunningham… - The lancet …, 2007 - thelancet.com
The past decade has seen pronounced changes in the treatment of locally advanced rectal
cancer. Historically, the standard of care involved surgery followed by adjuvant radiotherapy …

Multidisciplinary rectal cancer management: 2nd European rectal cancer consensus conference (EURECA-CC2)

V Valentini, C Aristei, B Glimelius, BD Minsky… - Radiotherapy and …, 2009 - Elsevier
BACKGROUND AND PURPOSE: During the first decade of the 21st century a number of
important European randomized studies were published. In order to help shape clinical …

Locally Advanced Rectal Cancer: MR Imaging in Prediction of Response after Preoperative Chemotherapy and Radiation Therapy1

B Barbaro, C Fiorucci, C Tebala, V Valentini… - Radiology, 2009 - pubs.rsna.org
Purpose: To prospectively differentiate, at magnetic resonance (MR) imaging, patients with
locally advanced nonmucinous rectal cancer who will respond to long-course chemotherapy …

Monitoring and predicting response to therapy with 18F-FDG PET in colorectal cancer: a systematic review

LF de Geus-Oei, D Vriens… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Molecular imaging with 18 F-FDG PET has been proven useful in the management of
colorectal cancer. 18 F-FDG PET plays a pivotal role in staging before surgical resection of …

18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer

GL Cascini, A Avallone, P Delrio, C Guida… - Journal of Nuclear …, 2006 - Soc Nuclear Med
18F-FDG PET is a useful tool for assessing the effects of chemo-or radiotherapy. The aim of
this study was to correlate the change in tumor 18F-FDG standardized uptake value (SUV) …

Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point

JG Guillem, DB Chessin, J Shia, HG Moore… - Journal of clinical …, 2005 - ascopubs.org
Purpose Clinical assessment of rectal cancer response to preoperative combined-modality
therapy (CMT) using digital rectal examination (DRE) has been proposed as a means of …

Monitoring response to treatment in patients utilizing PET

NE Avril, WA Weber - Radiologic Clinics, 2005 - radiologic.theclinics.com
The treatment of cancer patients is constantly evolving, striving for more efficient therapies
with fewer side effects. Chemotherapy and radiation therapy are still the major therapeutic …

Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer

SL Gearhart, D Frassica, R Rosen, M Choti… - Annals of surgical …, 2006 - Springer
Abstract Background 18 F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET)
and computed tomography (CT) are widely accepted in the evaluation for metastatic or …

Sequential FDG-PET/CT reliably predicts response of locally advanced rectal cancer to neo-adjuvant chemo-radiation therapy

C Capirci, L Rampin, PA Erba, F Galeotti… - European journal of …, 2007 - Springer
Purpose Prediction of rectal cancer response to preoperative, neo-adjuvant chemo-radiation
therapy (CRT) provides the opportunity to identify patients in whom a major response is …