[HTML][HTML] The connexin 43 C-terminus: A tail of many tales
Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …
communication between the cytosols of adjacent cells, create a unique cell signalling …
Role of TREK-1 in health and disease, focus on the central nervous system
A Djillani, J Mazella, C Heurteaux… - Frontiers in …, 2019 - frontiersin.org
TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …
excitability and maintain the membrane potential below the threshold of depolarization …
TREK-1 and TRAAK are principal K+ channels at the nodes of Ranvier for rapid action potential conduction on mammalian myelinated afferent nerves
Rapid conduction of nerve impulses is critical in life and relies on action potential (AP) leaps
through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites …
through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites …
Migraine-associated TRESK mutations increase neuronal excitability through alternative translation initiation and inhibition of TREK
P Royal, A Andres-Bilbe, PÁ Prado, C Verkest… - Neuron, 2019 - cell.com
It is often unclear why some genetic mutations to a given gene contribute to neurological
disorders and others do not. For instance, two mutations have previously been found to …
disorders and others do not. For instance, two mutations have previously been found to …
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier
TRAAK is a membrane tension-activated K+ channel that has been associated through
behavioral studies to mechanical nociception. We used specific monoclonal antibodies in …
behavioral studies to mechanical nociception. We used specific monoclonal antibodies in …
K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions
K2P potassium channels regulate cellular excitability using their selectivity filter (C-type)
gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels …
gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels …
Two-pore domain potassium channels as drug targets: anesthesia and beyond
A Mathie, EL Veale, KP Cunningham… - Annual review of …, 2021 - annualreviews.org
Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …
[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels
AM Natale, PE Deal, DL Minor Jr - Journal of molecular biology, 2021 - Elsevier
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
[HTML][HTML] Molecular mechanisms of cold pain
The sensation of cooling is essential for survival. Extreme cold is a noxious stimulus that
drives protective behaviour and that we thus perceive as pain. However, chronic pain …
drives protective behaviour and that we thus perceive as pain. However, chronic pain …
Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
F Wiedmann, N Frey, C Schmidt - Cells, 2021 - mdpi.com
Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …
resting membrane potential and modulate action potential repolarization. Members of the …