Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Among all non-communicable diseases, cancer is ranked as the second most common
cause of death and is rising constantly. While cancer treatments mainly include radiation …

Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition,
and mechanisms of action - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Triple‐negative breast cancer (TNBC) is a highly aggressive and uncommon subtype of
breast cancer with a poor prognosis. It is crucial to prioritise the creation of a …

A series of bufadienolides were isolated from the Bufo viridis toad venom, and their cytotoxic
activities against three human cancer cell lines (HeLa, HT-29, MCF7) and a non-cancer cell …

We report the design, synthetic route, and cytotoxicity of a library of 49 newly synthesized
tricyclic oxazolo [5, 4‐d] pyrimidines. The condensed pyrimidinones were constructed from …

A facile protocol was developed for the combinatorial synthesis of furo [2, 3-d] pyrimidinone
and pyrrolo [2, 3-d] pyrimidinone library via a one-pot condensation, from 2-amino …

The chemical transformation of the tricyclic furo [2, 3‐d] pyrimidines was performed under
isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine …

Herein, we studied the formation of thiones via C= O group conversion into the C= S
functional group-based tricyclic pyrimidinone systems using Lawesson's reagent and …

As mimetic compounds of the natural alkaloid mackinazolinone, forty pyrido [1, 2-a] thiazolo
[5, 4-d] pyrimidinone were designed and synthesized from a bioisosterism approach. The …