Disruptions of the blood–brain barrier (BBB) and edema formation both play key roles in the
development of neurological dysfunction in acute and chronic cerebral ischemia. Animal …

Recent laboratory findings suggest that it might be possible to promote cerebral plasticity
and neurological recovery after stroke by use of exogenous pharmacological or cell-based …

Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small
extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …

Matrix metalloproteinases (MMPs) are important in injury and recovery in ischemic injury.
They are proteolytic enzymes that degrade all components of the extracellular matrix (ECM) …

Reprogramming of adult human somatic cells to induced pluripotent stem cells (iPSCs) is a
novel approach to produce patient-specific cells for autologous transplantation. Whether …

It is now appreciated that emerging therapeutic strategies for recovery must include the
cerebral vasculature and that induction of angiogenesis will stimulate endogenous recovery …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

Ischemic stroke is one of the main issues threatening human health worldwide, and it is also
the main cause of permanent disability in adults. Energy consumption and hypoxia after …