Abstract MicroRNA-34 (miR-34) has been reported to be dysregulated in various human
cancers and regarded as a tumor suppressive microRNA because of its synergistic effect …

Senescence refers to the irreversible state in which cells enter cell cycle arrest due to
internal or external stimuli. The accumulation of senescent cells can lead to many age …

Background Accumulating evidence suggests that circular RNAs (circRNAs) are important
participants in cancer progression. However, the biological processes and underlying …

Abstract MiR-34b-5p has been reported as a non-invasive diagnostic biomarker for infertility.
However, no gene targets regulating the mechanism of cation of this miRNA are known. In …

Mesenchymal stem cell–derived extracellular vesicles (MSC-EV) can transport microRNAs
(miRNAs) into colorectal cancer (CRC) cells, thus to inhibit the malignant phenotype of …

Type I interferons (IFN) are cytokines that bridge the innate and adaptive immune response,
and thus play central roles in human health, including vaccine efficacy, immune response to …

Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Although
Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients …

Summary Ubiquitin-like (Ubl) post-translational modifications are potential targets for
therapeutics. However, the only known mechanism for inhibiting a Ubl-activating enzyme is …

SUMOylation plays an important role in tumor EMT, metastasis, therapy resistance, and
antitumor immune response. Pharmaceutical inhibition of SUMOylation has become …

Ionizing radiation may be of both artificial and natural origin and causes cellular damage in
living organisms. Radioactive isotopes have been used significantly in cancer therapy for …