Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Defective complement action is a cause of several human glomerular diseases including
atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated …

Extracellular vesicles (EV) are emerging mediators in several diseases. However, their role
in the pathophysiology of antibody-mediated allograft rejection (AMR) has been poorly …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

Kidney transplantation is the preferred renal replacement therapy available. Yet, long‐term
transplant survival is unsatisfactory, partially due to insufficient possibilities of longitudinal …

Delayed graft function (DGF) is defined as need for dialysis early posttransplant. DGF is
related to ischemia–reperfusion injury (IRI) that diminishes allograft function and may be …

Introduction Kidney transplant rejection remains an important clinical problem despite the
development of effective immunosuppressive therapy. Two major types of rejection are …

Extracellular vesicles are a diverse group of particles that include exosomes, microvesicles,
and apoptotic bodies and are defined by size, composition, site of origin, and density. They …

The complement system is paramount in the clearance of pathogens and cell debris, yet is
increasingly recognized as a key component in several pathways leading to allograft injury …