Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Discovered in late 1960, azoles are heterocyclic compounds class which constitute the
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

The cannabinoid 2 receptor (CB2R) has high therapeutic potential for multiple pathogenic
processes, such as neuroinflammation. Pathway‐selective ligands are needed to overcome …

Benzimidazole heterocycles are of great importance in medicinal chemistry due to their
applicability to a wide range of pharmacological targets, therefore representing a …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Diseases of the central nervous system are an alarming global problem showing an
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …

A series of 3-phenyl/ethyl-2-thioxo-2, 3-dihydrothiazolo [4, 5-d] pyrimidin-7-yl urea and
thiourea derivatives were designed and synthesized. All the compounds have been …

Psychiatric disorders like schizophrenia and neurodegenerative diseases like Parkinson's
disease are associated with poly-factorial pathogenic mechanisms, with several …

Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …