Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Iron metabolism is closely associated with the pathogenesis of obesity. However, the
mechanism of the iron-dependent regulation of adipocyte differentiation remains unclear …

The iron-and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …

Advances achieved with molecular biology and genomics technologies have permitted
investigators to discover epigenetic mechanisms, such as DNA methylation and histone …

Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and
mortality. Pathological LVH engages transcriptional programs including reactivation of …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Over the past few years it has become clear that vitamin C, as a provider of reduced iron, is
an essential factor for the function of epigenetic regulators that initiate the demethylation of …

Cardiovascular complications remain the leading causes of morbidity and premature
mortality in patients with diabetes mellitus. Studies in humans and preclinical models …