Tick saliva and the alpha-gal syndrome: finding a needle in a haystack

SR Sharma, S Karim - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in
tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the …

Environmental and molecular drivers of the α-Gal syndrome

A Cabezas-Cruz, A Hodžić… - Frontiers in …, 2019 - frontiersin.org
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab)
response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in …

EAACI molecular allergology user's guide 2.0

S Dramburg, C Hilger, AF Santos… - Pediatric Allergy and …, 2023 - Wiley Online Library
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Discovery of alpha-gal-containing antigens in North American tick species believed to induce red meat allergy

G Crispell, SP Commins, SA Archer-Hartman… - Frontiers in …, 2019 - frontiersin.org
Development of specific IgE antibodies to the oligosaccharide galactose-α-1, 3-galactose (α-
gal) following tick bites has been shown to be the source of red meat allergy. In this study …

Anti-Tick Microbiota Vaccine Impacts Ixodes ricinus Performance during Feeding

L Mateos-Hernández, D Obregón, J Maye, J Borneres… - Vaccines, 2020 - mdpi.com
The tick microbiota is a highly complex ensemble of interacting microorganisms. Keystone
taxa, with a central role in the microbial networks, support the stability and fitness of the …

The α-Gal syndrome and potential mechanisms

P Román-Carrasco, W Hemmer, A Cabezas-Cruz… - Frontiers in …, 2021 - frontiersin.org
The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

Current and future strategies for the diagnosis and treatment of the alpha-gal syndrome (AGS)

R Vaz-Rodrigues, L Mazuecos… - Journal of asthma and …, 2022 - Taylor & Francis
The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed
anaphylaxis in foods containing the oligosaccharide galactose-α-1, 3-galactose (α-Gal) such …

Controlling ticks and tick-borne diseases… looking forward

J de la Fuente - Ticks and tick-borne diseases, 2018 - Elsevier
Tick-borne diseases (TBDs) represent a growing burden for human and animal health
worldwide. Several approaches including the use of chemicals with repellency and …

Targeting a global health problem: Vaccine design and challenges for the control of tick-borne diseases

J de La Fuente, M Contreras, A Estrada-Peña… - Vaccine, 2017 - Elsevier
It has been over twenty years since the first vaccines for the control of tick infestations
became commercially available. These vaccines proved their efficacy and the potential of …

Galactose α-1, 3-galactose phenotypes: lessons from various patient populations

M Levin, D Apostolovic, T Biedermann… - Annals of Allergy …, 2019 - Elsevier
Objective To review published studies on galactose α-1, 3-galactose (α-gal), a carbohydrate
epitope found on proteins and lipids in nonprimate mammals and present in foods …