Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Parkinson's disease is a progressive neurodegenerative disorder resulting from the
degeneration of pigmented dopaminergic neurons in the substantia nigra pars compacta. It …

Although astrocytes are the most abundant cell type in the brain, evidence for their activation
during physiological sensory activity is lacking. Here we show that whisker stimulation …

In animals, sporadic injections of the mitochondrial toxin 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP) selectively damage dopaminergic neurons but do not fully …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Increased levels of extracellular glutamate and hyperactivation of glutamatergic receptors in
the basal ganglia trigger a critical cascade of events involving both intracellular pathways …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms
including tremor and bradykinesia. The primary pathophysiology underlying PD is the …

In recent years there have been tremendous advances in our understanding of the circuitry
of the basal ganglia and our ability to predict the behavioural effects of specific cellular …

Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …

Glutamate is the primary excitatory amino acid neurotransmitter in the CNS. The
concentration of glutamate in the synaptic cleft is tightly controlled by interplay between …