Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Background: Osteoarthritis (OA), as one of the chronic debilitating conditions, affects 15% of
people globally and is linked with serious problems, such as cardiovascular diseases …

Evolutionary responses to selection for bipedalism and childbirth have shaped the human
pelvis, a structure that differs substantially from that in apes. Morphology related to these …

Underlying variation in height are regulatory changes to chondrocytes, cartilage cells
comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

The identification of genomic loci that are associated with osteoarthritis (OA) has provided a
starting point for understanding how genetic variation activates catabolic processes in the …

The cancer genome is characterized by extensive variability, in the form of Single Nucleotide
Polymorphisms (SNPs) or structural variations such as Copy Number Alterations (CNAs) …

Objective Over 100 DNA variants have been associated with osteoarthritis (OA), including
rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 …

The ultimate goal of molecular genetic studies of human diseases is to translate the
discoveries for patient benefit. For diseases that lack licensed disease-modifying …

Genome-wide association studies have identified over 100 loci associated with osteoarthritis
risk, but the majority of osteoarthritis risk variants are noncoding, making it difficult to identify …