Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the
tumor suppressor protein p53. Genetically modified mouse models and human tumor …

Pancreatic cancer (PC) represents a group of malignant tumours originating from pancreatic
duct epithelial cells and acinar cells, and the 5-year survival rate of PC patients is only …

This review explores the progression of pancreatic intraepithelial neoplasia (PanIN) to
pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

The p53 family remains a captivating focus of an extensive number of current studies.
Accumulating evidence indicates that p53 abnormalities rank among the most prevalent in …

Adult pancreatic acinar cells show high plasticity allowing them to change in their
differentiation commitment. Pancreatic acinar-to-ductal metaplasia (ADM) is a cellular …

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. MicroRNAs (miRs) are
sensitive molecular diagnostic tools that can serve as highly accurate biomarkers in many …

Pancreatic cancer is known to be the most lethal cancer. Fewer new treatments are being
developed for pancreatic cancer as compared to other cancers. The bioactive lipid S1P …

Simple Summary Pancreatic cancer (PanCa) is one of the deadliest forms of cancer with
limited therapeutic options. The available conventional therapies are highly toxic and often …

Cancer continues to pose an alarming threat to global health, necessitating the need for the
development of efficient therapeutic solutions despite massive advances in the treatment …