The roles of insulin‐like growth factors in mesenchymal stem cell niche
Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue
regeneration therapies. However, the MSC availability in most tissues is limited which …
regeneration therapies. However, the MSC availability in most tissues is limited which …
[HTML][HTML] The regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes
Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal
stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in …
stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in …
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
Aging reduces the number of mesenchymal stem cells (MSCs) that can differentiate into
osteoblasts in the bone marrow, which leads to impairment of osteogenesis. However, if …
osteoblasts in the bone marrow, which leads to impairment of osteogenesis. However, if …
Stem cell therapy for osteoporosis
Osteoporosis is a debilitating disease that affects millions of people worldwide. Current
osteoporosis treatments are predominantly bone-resorbing drugs that are associated with …
osteoporosis treatments are predominantly bone-resorbing drugs that are associated with …
Reversing bone loss by directing mesenchymal stem cells to bone
Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is
problematic due to the inability to control the MSCs' commitment, growth, and differentiation …
problematic due to the inability to control the MSCs' commitment, growth, and differentiation …
Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1
MicroRNA-145 (miR-145) is downregulated in various tumor types. However, its mechanism
in inhibiting tumor growth and angiogenesis remains to be elucidated. In this study, we …
in inhibiting tumor growth and angiogenesis remains to be elucidated. In this study, we …
Mesenchymal Stem Cells Expressing Insulin-like Growth Factor-I (MSCIGF) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knockout Mice: Analyses of MSC …
F Granero-Moltó, TJ Myers, JA Weis, L Longobardi… - Stem Cells, 2011 - academic.oup.com
Failures of fracture repair (nonunions) occur in 10% of all fractures. The use of mesenchymal
stem cells (MSC) in tissue regeneration appears to be rationale, safe, and feasible. The …
stem cells (MSC) in tissue regeneration appears to be rationale, safe, and feasible. The …
IGFBP‐2 directly stimulates osteoblast differentiation
Insulin‐like growth factor binding protein 2 (IGFBP‐2) is important for acquisition of normal
bone mass in mice; however, the mechanism by which IGFBP‐2 functions is not defined …
bone mass in mice; however, the mechanism by which IGFBP‐2 functions is not defined …
TGF-β 3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling
Y Tao, X Zhou, C Liang, H Li, B Han, F Li, Q Chen - Growth factors, 2015 - Taylor & Francis
This study aimed to investigate the synergy between transforming growth factor beta 3 (TGF-
β3) and insulin-like growth factor 1 (IGF-1) on nucleus pulposus-derived mesenchymal stem …
β3) and insulin-like growth factor 1 (IGF-1) on nucleus pulposus-derived mesenchymal stem …
[HTML][HTML] MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1
S Melnik, J Gabler, SI Dreher, N Hecht… - Stem cell research & …, 2020 - Springer
Background Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative
therapy due to their chondrogenic differentiation potential. However, undesirable occurrence …
therapy due to their chondrogenic differentiation potential. However, undesirable occurrence …