Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

Background New antiretroviral therapy (ART) regimens for HIV could improve clinical
outcomes for patients. To inform global guidelines, we aimed to assess the comparative …

Background Tenofovir disoproxil fumarate can cause renal and bone toxic effects related to
high plasma tenofovir concentrations. Tenofovir alafenamide is a novel tenofovir prodrug …

Background Antiretroviral regimens containing tenofovir disoproxil fumarate have been
associated with renal toxicity and reduced bone mineral density. Tenofovir alafenamide is a …

Context New trial data and drug regimens that have become available in the last 2 years
warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency …

Abstract (See the editorial commentary by Yin and Overton, on pages 1705-7.) Background.
Long-term effects of abacavir (ABC)–lamivudine (3TC), compared with tenofovir (TDF) …

Systemic immune activation has emerged as an essential component of the
immunopathogenesis of HIV. It not only leads to faster disease progression, but also to …

Background Primary analyses of the SWORD-1 and SWORD-2 trials at 48 weeks showed
that switching to a two-drug regimen of dolutegravir plus rilpivirine was non-inferior to …

Objectives: To evaluate the safety and efficacy of the novel tenofovir prodrug, tenofovir
alafenamide (TAF), as part of a single-tablet regimen (STR) for the initial treatment of HIV-1 …

Although it has long been recognized that inflammation, a consequence of immune‐driven
processes, significantly impacts bone turnover, the degree of centralization of skeletal and …