Simple Summary Nitric oxide is an important molecule that performs a variety of functions in
our bodies, especially in the cardiovascular system. In certain pathological conditions, such …

Nitric oxide (NO) is one of the most important vasodilator molecules produced by the
endothelium. It has already been established that NO/cGMP signaling pathway deficiencies …

Rationale Development and progression of cardiovascular diseases, including
hypertension, are often associated with impaired nitric oxide synthase (NOS) function and …

The development of new organic nitrates is still relevant due to the clinical limitations of their
use. Tetrahydrofurfuryl nitrate (NTHF) is a new organic nitrate obtained through a synthetic …

Studies from our laboratory have shown that the nitric oxide (NO) donor 2-nitrate-1, 3-
dibutoxypropan (NDBP) lowers blood pressure in hypertension. However, the role of NDBP …

The methods used in preclinical studies should minimize the suffering and the number of
animals but still provide precise and consistent results enabling the introduction of drug …

Pharmacokinetic Properties using Graph-Based Signatures). Os parâmetros físicoquímicos
e a predição ADMET sugeriram que o NDIBP apresentou boa biodisponibilidade oral …

Os nitratos orgânicos são comumente utilizados no tratamento de doenças
cardiovasculares. Neste trabalho foi verificado o efeito farmacológico do mononitrato …

Актуальность. Много лет нитроглицерин служит основным средством купирования
коронарных болей у пациентов со стенокардией, однако его воздействие на …

As doenças cardiovasculares são a principal causa de mortes no mundo, matando cerca de
17 milhões de pessoas por ano, segundo a Organização Mundial de Saúde. Um dos …