Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features.
The incidence rate escalates. A high number of clones harboring various mutations …

Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

Metastasis is a leading cause of cancer‐related death and consists of a sequence of events
including tumor expansion, intravasation of cancer cells into the circulation, survival in the …

Simple Summary Tumour heterogeneity is a phenomenon where the cancer cells evolve
diversely over the course of the disease. As a result of the evolution, the cancer cells can be …

Background Knowledge of age‐related DNA methylation changes in skeletal muscle is
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …

DNA methylation is a fundamental epigenetic modification involved in various biological
processes and diseases. Analysis of DNA methylation data at a genome-wide and high …

DNA methylation is the most widely-studied epigenetic modification, playing a critical role in
the regulation of gene expression. Dysregulation of DNA methylation is implicated in the …

Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …