Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …

Glutamate is the most commonly engaged neurotransmitter in the mammalian central
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …