Thiazoles, their benzofused systems, and thiazolidinone derivatives: versatile and promising tools to combat antibiotic resistance
S Cascioferro, B Parrino, D Carbone… - Journal of medicinal …, 2020 - ACS Publications
Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized
as nuclei of great value for obtaining molecules with various biological activities, including …
as nuclei of great value for obtaining molecules with various biological activities, including …
ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents
Introduction: The bacterial topoisomerases DNA gyrase and topoisomerase IV are validated
targets for development of novel antibacterial agents. Fluoroquinolones inhibit the catalytic …
targets for development of novel antibacterial agents. Fluoroquinolones inhibit the catalytic …
Antibiofilm, antimicrobial, anti-quorum sensing, and antioxidant activities of Saudi Sidr Honey: in vitro and molecular docking studies
Sidr honey is a valuable source of bioactive compounds with promising biological
properties. In the present study, antimicrobial, antioxidant, and anti-quorum sensing …
properties. In the present study, antimicrobial, antioxidant, and anti-quorum sensing …
Discovery and hit-to-lead optimization of benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas …
We have developed compounds with a promising activity against Acinetobacter baumannii
and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant …
and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant …
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Z Skok, M Barančoková, O Benek… - ACS medicinal …, 2020 - ACS Publications
We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis
B Pakamwong, P Thongdee, B Kamsri… - Journal of Chemical …, 2022 - ACS Publications
Mycobacterium tuberculosis DNA gyrase manipulates the DNA topology using controlled
breakage and religation of DNA driven by ATP hydrolysis. DNA gyrase has been validated …
breakage and religation of DNA driven by ATP hydrolysis. DNA gyrase has been validated …
Identification of promising anti-DNA gyrase antibacterial compounds using de novo design, molecular docking and molecular dynamics studies
The rapidly increasing rate of antibiotic resistance is of great concern. Approximately two
million deaths result annually from bacterial infections worldwide. Therefore, there is a …
million deaths result annually from bacterial infections worldwide. Therefore, there is a …
Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria
SS Stokes, R Vemula, MJ Pucci - ACS Infectious Diseases, 2020 - ACS Publications
The prospect of ever increasing antibiotic resistance eroding currently available treatment
options for bacterial infections underscores the need to continue to identify new antibiotics …
options for bacterial infections underscores the need to continue to identify new antibiotics …
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors
ATP competitive inhibitors of DNA gyrase and topoisomerase IV have great therapeutic
potential, but none of the described synthetic compounds has so far reached the market. To …
potential, but none of the described synthetic compounds has so far reached the market. To …
Total synthesis of kibdelomycin
A modular total synthesis of kibdelomycin is disclosed that should enable structure–activity
relationship (SAR) studies of this interesting class of antibiotics. The route uses simple …
relationship (SAR) studies of this interesting class of antibiotics. The route uses simple …