A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
[HTML][HTML] Programming cytomegalovirus as an HIV vaccine
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis
Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely
innate lymphocytes by demonstrating that they are capable of putative antigen-specific …
innate lymphocytes by demonstrating that they are capable of putative antigen-specific …
Intracellular trafficking of HLA-E and its regulation
W He, E Gea-Mallorquí, H Colin-York… - Journal of Experimental …, 2023 - rupress.org
Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …
[HTML][HTML] Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
D Malouli, RM Gilbride, HL Wu, JM Hwang, N Maier… - Cell host & …, 2022 - cell.com
Strain 68-1 rhesus cytomegalovirus expressing simian immunodeficiency virus (SIV)
antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in …
antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in …
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
MC Verweij, SG Hansen, R Iyer, N John, D Malouli… - Science, 2021 - science.org
INTRODUCTION Strain 68-1 rhesus cytomegalovirus (RhCMV) vaccine vectors expressing
simian immunodeficiency virus (SIV) antigens elicit immune responses that stringently …
simian immunodeficiency virus (SIV) antigens elicit immune responses that stringently …
[HTML][HTML] Harnessing donor unrestricted T-cells for new vaccines against tuberculosis
Abstract Mycobacterium bovis bacille Calmette-Guérin (BCG) prevents extrapulmonary
tuberculosis (TB) and death among infants but fails to consistently and sufficiently prevent …
tuberculosis (TB) and death among infants but fails to consistently and sufficiently prevent …
[HTML][HTML] Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding
LC Walters, K Harlos, S Brackenridge… - Nature …, 2018 - nature.com
Through major histocompatibility complex class Ia leader sequence-derived (VL9) peptide
binding and CD94/NKG2 receptor engagement, human leucocyte antigen E (HLA-E) reports …
binding and CD94/NKG2 receptor engagement, human leucocyte antigen E (HLA-E) reports …
Complete sequencing of a cynomolgus macaque major histocompatibility complex haplotype
JA Karl, TM Prall, HE Bussan, JM Varghese… - Genome …, 2023 - genome.cshlp.org
Macaques provide the most widely used nonhuman primate models for studying the
immunology and pathogenesis of human diseases. Although the macaque major …
immunology and pathogenesis of human diseases. Although the macaque major …
[HTML][HTML] SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a
natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of …
natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of …