Stigmasterol Exerts an Anti-Melanoma Property through Down-Regulation of Reactive Oxygen Species and Programmed Cell Death Ligand 1 in Melanoma Cells

NR Han, HJ Park, SG Ko, PD Moon - Antioxidants, 2024 - mdpi.com
Cancer immunotherapy as a promising anti-cancer strategy has been widely studied in
recent years. Stigmasterol (STIG), a phytosterol, is known to have various pharmacological …

Network Pharmacology and Experimental Validation to Explore the Potential Mechanism of Nigella sativa for the Treatment of Breast Cancer

R Arif, SA Bukhari, G Mustafa, S Ahmed, MF Albeshr - Pharmaceuticals, 2024 - mdpi.com
Breast cancer is a prevalent and potentially life-threatening disease that affects women
worldwide. Natural products have gained attention as potential anticancer agents due to …

Limonoids, triterpenes, sterols, and flavonoids from Cedrela odorata L. and their cytotoxic activity

V Vasquez-Ruiz, AE Bañuelos-Hernández… - Tetrahedron, 2024 - Elsevier
Abstract The isoflavonoid cedrelin (1), isolated for the first time, and two new limonoids with
mexicanolide skeleton, the 15-O-acetyl-12-oxo-fissinolide (2) and 15-O-acetyl-fissinolide (3) …

Density functional theory and spectroscopic analysis of stigmasterol from Garcinia wightii: Deciphering its inhibitory potential against drug-resistant tuberculosis via …

SV Aswathy, IH Joe, KB Rameshkumar - Journal of Molecular Structure, 2025 - Elsevier
This study investigates the molecular structure and electronic properties of stigmasterol,
isolated from Garcinia wightii, using density functional theory (DFT) alongside experimental …

Enhancing the effectiveness of paclitaxel with stigmasterol bioactive compounds for cancer treatment

HA Hussein, FL Khaphi, RM Jassem - International Journal of Innovative …, 2024 - ijirss.com
This study examines the anticancer activity of stigmasterol bioactive compounds combined
with paclitaxel. Drug resistance and high toxicity in chemotherapy present a challenge in …