Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases

L Cianni, F dos Reis Rocho, F Rosini, V Bonatto… - Bioorganic …, 2020 - Elsevier
Cysteine proteases (CPs) are involved in a myriad of actions that include not only protein
degradation, but also play an essential biological role in infectious and systemic diseases …