A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

Major goal of structural biology involve formation of protein-ligand complexes; in which the
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …

Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential"
druggability" for thousands of cysteine residues. Consequently, these studies are facilitating …

The aim of this study was to identify a candidate drug for the development of anti-
tuberculosis therapy from previously synthesized compounds based on the …

Cysteine proteases of the papain superfamily are implicated in a number of cellular
processes and are important virulence factors in the pathogenesis of parasitic disease …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit
the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new …

A series of novel thiosemicarbazone derivatives bearing condensed heterocyclic
carboxaldehyde moieties were designed and synthesized. Among them, TSC24 exhibited …

Malaria has been teasing human populations from a long time. Presently, several classes of
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …

Chemical communication is a phenomenon exhibited by many different organisms and
nowadays is one of the most prominent research areas at the chemistry-microbiology …