Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Smoking represents one of the most important preventable risk factors for the development
of atherosclerosis. The present review aims at providing a comprehensive summary of …

Electronic (e)-cigarettes theoretically may be safer than conventional tobacco. However, our
prior studies demonstrated direct adverse effects of e-cigarette vapor (EV) on airway cells …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …

Cardiovascular morbidity and mortality as a result of inhaled tobacco products continues to
be a global healthcare crisis, particularly in low-and middle-income nations lacking the …

This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking,
are major lung diseases affecting millions of individuals worldwide. The generated gas …

Hypertension is a major contributor to the development of renal failure, cardiovascular
disease, and stroke. These pathologies are associated with vascular functional and …

One of the major conceptual advances in our understanding of the pathogenesis of age-
associated cardiovascular diseases has been the insight that age-related oxidative stress …