Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …

Background Delirium is a common neurocognitive complication after cardiac surgery. The
aim of this systematic review was to determine whether the administration of …

Offering up-to-date coverage of everything from historical and international perspectives to
basic science and today's clinical practice, Miller's Anesthesia, 10th Edition, remains the# 1 …

To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …

Clinical research into consciousness has long focused on cortical macroscopic networks
and their disruption in pathological or pharmacological consciousness perturbation. Despite …

General anesthesia reversibly alters consciousness, without shutting down the brain
globally. Depending on the anesthetic agent and dose, it may produce different …

What happens in the brain when conscious awareness of the surrounding world fades? We
manipulated consciousness in two experiments in a group of healthy males and measured …

What happens in the human brain when we are unconscious? Despite substantial work, we
are still unsure which brain regions are involved and how they are impacted when …

Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic,
analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative …

Macaque monkeys are an important animal model where invasive investigations can lead to
a better understanding of the cortical organization of primates including humans. However …