Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a
number of neurological conditions compared with healthy controls (HC) and is a candidate …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most
patients. The early phase is characterised by relapses and the later phase by progressive …

Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

Background Cortical disease has emerged as a critical aspect of the pathogenesis of
multiple sclerosis, being associated with disease progression and cognitive impairment …

Multiple sclerosis is characterized at the gross pathological level by the presence of
widespread focal demyelinating lesions of the myelin-rich white matter. However, it is …

Meningeal inflammation in the form of ectopic lymphoid-like structures has been suggested
to play a prominent role in the development of cerebral cortical grey matter pathology in …

Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …

Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

There has been significant progress in our understanding of the pathology and
pathogenesis of central nervous system inflammatory demyelinating diseases …