Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

It is becoming clear that the manner by which the immune response resolves or contains
infection by a pathogen varies according to the tissue that is affected. Unlike many …

In the central nervous system (CNS), innate immune surveillance is mainly coordinated by
microglia. These CNS resident myeloid cells are assumed to help orchestrate the immune …

The infection of the central nervous system (CNS) with neurotropic viruses induces
neuroinflammation and is associated with the development of neuroinflammatory and …

Viral encephalitis is a major risk factor for the development of seizures, epilepsy, and
hippocampal damage with associated cognitive impairment, markedly reducing quality of life …

Viral encephalitis is a major risk factor for the development of seizures and epilepsy, but the
underlying mechanisms are only poorly understood. Mouse models such as viral …

Infections, particularly those caused by viruses, are among the main causes of acquired
epilepsy, but the mechanisms causing epileptogenesis are only poorly understood. As a …

Background Viral encephalitis is a dangerous compromise between the need to robustly
clear pathogen from the brain and the need to protect neurons from bystander injury …

Background The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy
may provide a therapeutic target for reduction of seizure burden in patients that are currently …

Background Aberrant neuroinflammation is suspected to contribute to the pathogenesis of
myriad neurological diseases. As such, determining the pathways that promote or inhibit …