The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …

The complement system is a central component of innate immunity and bridges the innate to
the adaptive immune response. However, it can also turn its destructive capabilities against …

Introduction: The complement system is essential for an adequate immune response. Much
attention has been given to the role of complement in disease. However, to better …

The complement system is an essential component of innate immunity that has been more
recently recognized as an unexpected player in various pathological states. These include …

Therapeutic modulation of the human complement system is considered a promising
approach for treating a number of pathological conditions. Owing to its central position in the …

Traumatic brain injury (TBI) is a leading cause of mortality, sensorimotor morbidity, and
neurocognitive disability. Neuroinflammation is one of the key drivers causing secondary …

Abstract Objective C1 inhibitor (C1‐INH) is an endogenous inhibitor of complement and
kinin systems. We have explored the efficacy and the therapeutic window of the recently …

Background: Intravenous (IV) iron preparations are widely used in the treatment of anemia in
patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing …

Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys
disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in …

The host is protected by pattern recognition systems, including complement and TLRs,
which are closely cross-talking. If improperly activated, these systems might induce tissue …