The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …

The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

The gonadotrophin‐releasing hormone (GnRH) neurones represent the final output
neurones of a complex neuronal network that controls fertility. It is now appreciated that …

Sleep, like breathing, is a biologic rhythm that is actively generated by the brain. Neuronal
networks that have evolved to regulate naturally occurring sleep preferentially modulate …

Whole cell patch-clamp recordings were obtained from thalamic ventrobasal (VB) and
reticular (RTN) neurons in mouse brain slices. A bicuculline-sensitive tonic current was …

General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

Urethane is widely used in neurophysiological experiments to anesthetize animals, yet little
is known about its actions at the cellular and synaptic levels. This limits our ability to model …

Neuroactive steroids have some of their most potent actions by augmenting the function of
GABAA receptors. Endogenous steroid actions on GABAA receptors may underlie important …

Intraoperative Awareness Page 1 Intraoperative Awareness From Ether Day to THRIVE George
A. Mashour, MD, Ph.D. Robert B. Sweet Professor & Chair, Department of Anesthesiology …

Alcohol withdrawal syndrome (AWS) symptoms include hyperexcitability, anxiety, and sleep
disorders. Chronic intermittent ethanol (CIE) treatment of rats with subsequent withdrawal of …