Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a
fundamental role in metazoan development. Signals exchanged between neighboring cells …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind
as dimers to specific DNA target sites and that have been well characterized in nonplant …

TRANSCRIPTIONAL silencing mediated by nuclear receptors is important in development,
differentiation and oncogenesis1-3. The mechanism underlying this effect is unknown but is …

The transcriptional response to auxin is critical for root and vascular development during
Arabidopsis embryogenesis. Auxin induces the degradation of AUXIN/INDOLE-3-ACETIC …

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as
both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR) …

We have identified and characterized c-hairy1, an avian homolog of the Drosophila
segmentation gene, hairy. c-hairy1 is strongly expressed in the presomitic mesoderm, where …

The KRAB repression domain is one of the most widely distributed transcriptional effector
domains yet identified, but its mechanism of repression is unknown. We have cloned a …

Wingless/Wnt signalling directs cell-fate choices during embryonic development,.
Inappropriate reactivation of the pathway causes cancer,,. In Drosophila, signal transduction …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …