Genomic profiling in renal cell carcinoma

N Dizman, EJ Philip, SK Pal - Nature reviews nephrology, 2020 - nature.com
The treatment landscape of metastatic renal cell carcinoma (RCC) has been revolutionized
over the past two decades, bringing forth an era in which more than a dozen therapeutic …

Prognostic factors and predictive models in renal cell carcinoma: a contemporary review

M Sun, SF Shariat, C Cheng, V Ficarra, M Murai… - European urology, 2011 - Elsevier
CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …

Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting

B Beuselinck, S Job, E Becht, A Karadimou… - Clinical cancer …, 2015 - AACR
Purpose: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who
might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our …

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma

R Culliford, SED Lawrence, C Mills, Z Tippu… - Nature …, 2024 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a
comprehensive description of its genomic landscape is lacking. We report the whole …

Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics

WM Linehan - Genome research, 2012 - genome.cshlp.org
Kidney cancer is not a single disease; it is made up of a number of different types of cancer,
including clear cell, type 1 papillary, type 2 papillary, chromophobe, TFE3, TFEB, and …

Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma

Y Ohno, J Nakashima, M Ohori, T Hatano… - The Journal of …, 2010 - Elsevier
PURPOSE: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio
to predict recurrence in patients with nonmetastatic renal cell carcinoma. MATERIALS AND …

Renal tumors: diagnostic and prognostic biomarkers

PH Tan, L Cheng, N Rioux-Leclercq… - The American journal …, 2013 - journals.lww.com
Abstract The International Society of Urological Pathology convened a consensus
conference on renal cancer, preceded by an online survey, to address issues relating to the …

Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy

AB Stillebroer, PFA Mulders, OC Boerman, WJG Oyen… - European urology, 2010 - Elsevier
CONTEXT: The clinical management of patients with renal cell carcinoma (RCC) remains
difficult, and the development of new diagnostic, prognostic, and therapeutic tools is still …

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

LE Moore, ML Nickerson, P Brennan, JR Toro… - PLoS …, 2011 - journals.plos.org
Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify
disease into molecularly defined subtypes to examine associations with etiologic risk factors …

State of the science: an update on renal cell carcinoma

E Jonasch, PA Futreal, IJ Davis, ST Bailey… - Molecular cancer …, 2012 - AACR
Renal cell carcinomas (RCC) are emerging as a complex set of diseases that are having a
major socioeconomic impact and showing a continued rise in incidence throughout the …